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  "Title": "Variance stabilization and calibration for microarray data",
  "Authors@R": "c(\nperson(\"Wolfgang\", \"Huber\", email=\"wolfgang.huber@embl.org\", role = c(\"aut\",\"cre\")),\nperson(\"Anja\", \"von Heydebreck\", role = c(\"aut\")),\nperson(\"Dennis\", \"Kostka\", role = c(\"ctb\")),\nperson(\"David\", \"Kreil\", role = c(\"ctb\")),\nperson(\"Hans-Ulrich\", \"Klein\", role = c(\"ctb\")),\nperson(\"Robert\", \"Gentleman\", role = c(\"ctb\")),\nperson(\"Deepayan\", \"Sarkar\", role = c(\"ctb\")),\nperson(\"Gordon\", \"Smyth\", role = c(\"ctb\")),\nperson(\"Federal Ministry of Research, Technology and Space of Germany, DHGP\", role=\"fnd\"))",
  "Maintainer": "Wolfgang Huber <wolfgang.huber@embl.org>",
  "Description": "The package implements a method for normalising microarray\nintensities from single- and multiple-color arrays. It can also\nbe used for data from other technologies, as long as they have\nsimilar format. The method uses a robust variant of the\nmaximum-likelihood estimator for an additive-multiplicative\nerror model and affine calibration. The model incorporates data\ncalibration step (a.k.a. normalization), a model for the\ndependence of the variance on the mean intensity and a variance\nstabilizing data transformation. Differences between\ntransformed intensities are analogous to \"normalized\nlog-ratios\". However, in contrast to the latter, their variance\nis independent of the mean, and they are usually more sensitive\nand specific in detecting differential transcription.",
  "Reference": "[1] Variance stabilization applied to microarray data\ncalibration and to the quantification of differential\nexpression, Wolfgang Huber, Anja von Heydebreck, Holger\nSueltmann, Annemarie Poustka, Martin Vingron; Bioinformatics\n(2002) 18 Suppl1 S96-S104. [2] Parameter estimation for the\ncalibration and variance stabilization of microarray data,\nWolfgang Huber, Anja von Heydebreck, Holger Sueltmann,\nAnnemarie Poustka, and Martin Vingron; Statistical Applications\nin Genetics and Molecular Biology (2003) Vol. 2 No. 1, Article\n3; http://www.bepress.com/sagmb/vol2/iss1/art3.",
  "License": "Artistic-2.0",
  "URL": "https://github.com/Huber-group-EMBL/vsn,\nhttps://huber-group-embl.github.io/vsn/",
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  "Date/Publication": "2026-09-23 11:27:07 UTC",
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  "Author": "Wolfgang Huber [aut, cre],\nAnja von Heydebreck [aut],\nDennis Kostka [ctb],\nDavid Kreil [ctb],\nHans-Ulrich Klein [ctb],\nRobert Gentleman [ctb],\nDeepayan Sarkar [ctb],\nGordon Smyth [ctb],\nFederal Ministry of Research, Technology and Space of Germany, DHGP\n[fnd]",
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