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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "vsn" in publications use:'
type: software
license: Artistic-2.0
title: 'vsn: Variance stabilization and calibration for microarray data'
version: 3.79.6
doi: 10.1093/bioinformatics/18.suppl_1.s96
identifiers:
- type: doi
  value: 10.32614/CRAN.package.vsn
abstract: The package implements a method for normalising microarray intensities from
  single- and multiple-color arrays. It can also be used for data from other technologies,
  as long as they have similar format. The method uses a robust variant of the maximum-likelihood
  estimator for an additive-multiplicative error model and affine calibration. The
  model incorporates data calibration step (a.k.a. normalization), a model for the
  dependence of the variance on the mean intensity and a variance stabilizing data
  transformation. Differences between transformed intensities are analogous to "normalized
  log-ratios". However, in contrast to the latter, their variance is independent of
  the mean, and they are usually more sensitive and specific in detecting differential
  transcription.
authors:
- family-names: Huber
  given-names: Wolfgang
  email: wolfgang.huber@embl.org
- family-names: Heydebreck
  given-names: Anja
  name-particle: von
preferred-citation:
  type: article
  title: Variance Stabilization Applied to Microarray Data Calibration and to the
    Quantification of Differential Expression
  authors:
  - family-names: Huber
    given-names: Wolfgang
    email: wolfgang.huber@embl.org
  - family-names: Heydebreck
    given-names: Anja
    name-particle: von
  - family-names: Sueltmann
    given-names: Holger
  - family-names: Poustka
    given-names: Annemarie
  - family-names: Vingron
    given-names: Martin
  doi: 10.1093/bioinformatics/18.suppl_1.s96
  journal: Bioinformatics
  year: '2002'
  volume: 18 Suppl. 1
  start: S96-S104
repository: https://huber-group-embl.r-universe.dev
repository-code: https://github.com/Huber-group-EMBL/vsn
commit: 3ee872b304d920079f65cd3113794411d805d15f
url: https://github.com/Huber-group-EMBL/vsn
date-released: '2026-03-27'
contact:
- family-names: Huber
  given-names: Wolfgang
  email: wolfgang.huber@embl.org